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PyFerret is a Python module wrapping Ferret. Ferret is an interactive computer visualization and analysis environment designed to meet the needs of oceanographers and meteorologists analyzing large and complex gridded data sets. Ferret was developed by the Thermal Modeling and Analysis Project (TMAP) at PMEL in Seattle to analyze the outputs of its numerical ocean models and compare them with gridded, observational data. The model data sets are generally multi-gigabyte in size with mixed multi-dimensional variables defined on staggered grids. Ferret offers a Mathematica-like approach to analysis; new variables may be defined interactively as mathematical expressions involving data set variables. Calculations may be applied over arbitrarily shaped regions. Fully documented graphics are produced with a single command.